Exogenous itaconate addition in apolipoprotein E-deficient (Apoe?/?) mice suppressed the initiation and progression of AAA and downstream inflammatory protein even though Irg1 deficiency reverted the outcome of inhibitory. Overexpression of Keap1 or transferred Cys151S mutant Keap1 vector also abolished the activation of Nrf2 induced by itaconate.A

Perhaps, the gut microbiota dysbiosis with reduce in immunosuppressive species and reduce in immune enhancing species in recipients could encourage AMR by means of maximizing the donor precise antibody response.Completely, our results furnished a comprehensive and in-depth understanding of the correlation among AMR and gut microbiota, which is esse